Ontological labels for automated location of anatomical shape differences

► Visual inspection found significant expansion in mid-anterior of left ventricle. ► High resolution human LV atlas labeled with terms from large reference ontology. ► Atlas mapped to previous study's coordinates. Semantic tools used to query. ► Automated methods found same region in apical anterior. Other metrics agree. ► A formal, precise, automated, and reproducible way to make location-based inferences.