کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10356111 867614 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transfer learning of classification rules for biomarker discovery and verification from molecular profiling studies
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
Transfer learning of classification rules for biomarker discovery and verification from molecular profiling studies
چکیده انگلیسی
We present a novel framework for integrative biomarker discovery from related but separate data sets created in biomarker profiling studies. The framework takes prior knowledge in the form of interpretable, modular rules, and uses them during the learning of rules on a new data set. The framework consists of two methods of transfer of knowledge from source to target data: transfer of whole rules and transfer of rule structures. We evaluated the methods on three pairs of data sets: one genomic and two proteomic. We used standard measures of classification performance and three novel measures of amount of transfer. Preliminary evaluation shows that whole-rule transfer improves classification performance over using the target data alone, especially when there is more source data than target data. It also improves performance over using the union of the data sets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomedical Informatics - Volume 44, Supplement 1, December 2011, Pages S17-S23
نویسندگان
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