کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10356171 867619 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simulated pathogenic conformational switch regions matched well with the biochemical findings
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
Simulated pathogenic conformational switch regions matched well with the biochemical findings
چکیده انگلیسی
Pathogenic conformational conversion is a general causation of many disease, such as transmissible spongiform encephalopathy (TSE) caused by misfolding of prion, sickle cell anemia, and etc. In such structural changes, misfolding occurs in regions important for the stability of native structure firstly. This destabilizes the normal conformation and leads to subsequent errors in folding pathway. Sites involved in the first stage can be deemed switch regions of the protein, and are vital for conformational conversion. Namely it could be a switch of disease at residue level. Here we report an algorithm that can identify such sites computationally with an accuracy of 93%, by calculating the probability of the native structure of a short segment jumping to a mistake one. Knowledge of such switch sites could be used to target clinical therapy, study physiological and pathologic mechanism of protein, and etc.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomedical Informatics - Volume 43, Issue 3, June 2010, Pages 365-375
نویسندگان
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