کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10356505 | 867795 | 2005 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fluorescence photon migration by the boundary element method
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
نرم افزارهای علوم کامپیوتر
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چکیده انگلیسی
The use of the boundary element method (BEM) is explored as an alternative to the finite element method (FEM) solution methodology for the elliptic equations used to model the generation and transport of fluorescent light in highly scattering media, without the need for an internal volume mesh. The method is appropriate for domains where it is reasonable to assume the fluorescent properties are regionally homogeneous, such as when using highly specific molecularly targeted fluorescent contrast agents in biological tissues. In comparison to analytical results on a homogeneous sphere, BEM predictions of complex emission fluence are shown to be more accurate and stable than those of the FEM. Emission fluence predictions made with the BEM using a 708-node mesh, with roughly double the inter-node spacing of boundary nodes as in a 6956-node FEM mesh, match experimental frequency-domain fluorescence emission measurements acquired on a 1087Â cm3 breast-mimicking phantom at least as well as those of the FEM, but require only 1/8 to 1/2 the computation time.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Computational Physics - Volume 210, Issue 1, 20 November 2005, Pages 109-132
Journal: Journal of Computational Physics - Volume 210, Issue 1, 20 November 2005, Pages 109-132
نویسندگان
Francesco Fedele, Margaret J. Eppstein, Jeffrey P. Laible, Anuradha Godavarty, Eva M. Sevick-Muraca,