Investigation of the interactions of lupane type pentacyclic triterpenes with outer leaflet membrane phospholipids - Langmuir monolayer and synchrotron X-ray scattering study

► Lupane type triterpenes (LTs) in mixed Langmuir monolayers with phospholipids. ► Modeling of the mode of action of these active natural products. ► Lost of monolayer periodicity after LT incorporation (disappearance of GIXD signal). ► Lupeol and betulinic acid have different modes of action.