Thermodynamic properties of micellization of Sulfobetaine-type Zwitterionic Gemini Surfactants in aqueous solutions - A free energy perturbation study

► Micellization of Sulfobetaine Zwitterionic Gemini Surfactants is entropy-driven. ► The enthalpy-entropy compensation temperature is (302 ± 3) K. ► The contribution of enthalpy increases with temperature. ► A longer spacer chain length can enhance the formation and stability of micelles. ► Thermodynamic results are similar to the anionic rather than cationic surfactants.