Thermo-responsive monodisperse core-shell microspheres with PNIPAM core and biocompatible porous ethyl cellulose shell embedded with PNIPAM gates

► Novel core-shell microspheres are prepared for thermo-responsive controlled release. ► Microcapsules are composed of biocompatible shell and thermo-responsive core. ► Thermo-responsive gates are synthesized in situ in the membrane pores of capsules.