Interaction of chitosan and mucin in a biomembrane model environment

► Electrostatic interactions govern interaction between mucin and chitosan in a cell membrane model. ► Mucin expands Langmuir monolayers from negatively charged phospholipid. ► Chitosan is able to remove mucin from a phospholipid monolayer. ► Desorption of mucin from LB films was induced by chitosan.