Interaction via in situ binding of CdS nanorods onto gelatin

► CdSNRs bond to amide and carboxylic groups of gelatin long chains through electrostatic interactions. ► The interaction of CdS with gelatin led to a more polar environment for tyrosine and tryptophan residues. ► The molecular structure of gelatin has been destroyed, and relevant physiological functions are lost or changed. ► The results provide useful information for exploring the mechanism of interaction between nanoparticle and fibrous protein.