کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10378765 | 880762 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Resistance of zwitterionic telomers accumulated on metal surfaces against nonspecific adsorption of proteins
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Telomers of N,N-dimethyl-N-(3-sulfopropyl)-3â²-methacryloylaminopropanaminium inner salt (SPB), 2-methacryloyloxyethyl phosphorylcholine (MPC), and N,N-dimethyl-N-(1-carboxymethyl)-2â²-methacryloyloxylethanaminium inner salt (CMB) were prepared by UV irradiation in the presence of N,N,Nâ²,Nâ²-tetraethylthiuram disulfide and a disulfide-group-carrying iniferter (a compound which pursues initiation, chain transfer, and termination), Cys-BDC, which had been prepared by coupling N,N-diethyldithiocarbamoylmethylbenzoic acid succinimidyl ester with cystamine dihydrochloride. The telomers formed a self-assembled monolayer (SAM) on a gold electrode and a monolayer of colloidal gold deposited on a glass plate, as confirmed by the increase in potential difference (ÎEp) of the voltammogram for hydroquinone as a probe using cyclic voltammetry (CV) and the increase in absorbance using localized surface plasmon resonance (LSPR) absorption spectroscopy, respectively. Nonspecific adsorption of various proteins onto the surfaces of various telomer SAMs was examined from the decrease in peak current (ÎI) using CV and the absorption increase at 550 nm using LSPR absorption spectroscopy. The zwitterionic telomer SAM in general did not adsorb proteins significantly, suggesting the usability of zwitterionic polymer SAMs and brushes to coat various materials used in biomedical fields. The correlation between the structure of water in the vicinity of zwitterionic telomers and the resistance of the zwitterionic telomer SAMs against the nonspecific adsorption of proteins was discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 282, Issue 2, 15 February 2005, Pages 340-348
Journal: Journal of Colloid and Interface Science - Volume 282, Issue 2, 15 February 2005, Pages 340-348
نویسندگان
Hiromi Kitano, Akio Kawasaki, Hideaki Kawasaki, Shinta Morokoshi,