Non-invasive glucose sensing with near-infrared spectroscopy enhanced by optical measurement conditions reproduction technique

Non-invasive glucose sensing utilizing near-infrared spectroscopy (NIRS) has been a focusing topic in biomedical optics applications. However, different probing locations and contact pressures between the probe and skin cause variations in the light propagation paths within tissue, making it very hard to obtain stable near-infrared spectra concerning body content. This paper proposes one possible solution to the reproduction of light propagation within tissue for near-infrared non-invasive glucose sensing systems by introducing the optical measurement conditions reproduction technique. Results of experiments on glucose concentrations within human body through application of our proposed system show a RMSEP value of 15-20 mg/dL and a correlation coefficient greater than 0.8.