کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10408928 893748 2005 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of the optical second harmonic response of pharmaceutical solid-solid mixtures
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی برق و الکترونیک
پیش نمایش صفحه اول مقاله
Determination of the optical second harmonic response of pharmaceutical solid-solid mixtures
چکیده انگلیسی
We report on a new method for characterising crystallinity and polymorphism of pharmaceutical drugs and excipients in the solid state. The optical nonlinearity of certain crystalline structures allows under certain circumstances the quantitative determination of polymorphism or crystallinity. An apparatus was set up to measure the second harmonic response of powdered samples when irradiated with a pulsed laser source. Here we present experimental results from various pharmaceutically interesting materials. This rapid, novel technique has potential for industrial monitoring of pharmaceutical manufacturing processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Optics and Lasers in Engineering - Volume 43, Issue 2, February 2005, Pages 209-220
نویسندگان
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