کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10409084 | 893935 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Integrated miniaturized optical detection platform for fluorescence and absorption spectroscopy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
الکتروشیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Integrated miniaturized optical detection platform for fluorescence and absorption spectroscopy Integrated miniaturized optical detection platform for fluorescence and absorption spectroscopy](/preview/png/10409084.png)
چکیده انگلیسی
This paper presents the design and fabrication of a miniaturized optical detection system for sensing in microchannels, based on integrated optical waveguide technology. This design allows the implementation of both absorption and fluorescence measurement schemes and can be potentially integrated into a lab-on-a-chip system. An array of optical waveguides were fabricated in spin-on polymer technology on a silicon substrate and monolithically integrated with the microfluidic channel and V-groove fibre alignment scheme. The design was adapted to achieve minimum optical losses under the imposed fabrication constraints. Total system losses with a water filled microchannel were experimentally determined to be 10.45 dB. Both fluorescence and absorption detection capabilities of the fabricated device were demonstrated using Alexa Fluor 633 dye, and the corresponding detection limits were found to be 10 nM and 1 μM, respectively. Several areas of improvements in the device design and fabrication have been identified for future works towards better integration for lab-on-a-chip system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators A: Physical - Volume 135, Issue 2, 15 April 2007, Pages 515-524
Journal: Sensors and Actuators A: Physical - Volume 135, Issue 2, 15 April 2007, Pages 515-524
نویسندگان
Lidija Malic, Andrew G. Kirk,