کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10410266 894328 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amperometric glucose microbiosensor based on a Prussian Blue modified carbon fiber electrode for physiological applications
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Amperometric glucose microbiosensor based on a Prussian Blue modified carbon fiber electrode for physiological applications
چکیده انگلیسی
Results of experiments in vitro and in vivo, using an amperometric glucose microbiosensor based on a Prussian Blue (PB) modified carbon fiber electrode with very low dimensions (∼10 μm diameter), are presented. The electrocatalytic properties of the PB film enable detection of an enzymatic by-product (H2O2) at a very low applied potential: 0.0 V against SCE. The main steps during glucose microbiosensor construction were examined by cyclic voltammetry and electrochemical impedance spectroscopy. Excellent selectivity of the glucose microbiosensors against a large number of physiological interference compounds is demonstrated. Finally, microbiosensor responses during intraperitoneal injection, local infusion and local electrical stimulation showed sufficient sensitivity and stability to monitor multi-phasic and reversible changes in brain ECF glucose levels during physiological experiments, illustrating the excellent properties and utility of this biosensor design in the neurosciences.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 152, Issue 2, 1 March 2011, Pages 137-143
نویسندگان
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