کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10410902 | 894532 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glucose recovery in a microfluidic microdialysis biochip
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Glucose recovery in a microfluidic microdialysis biochip Glucose recovery in a microfluidic microdialysis biochip](/preview/png/10410902.png)
چکیده انگلیسی
Microdialysis is a technique for separating biomolecules by controlling the mass transfer rate of biomolecules diffusing across a semipermeable membrane. It has been used in the medical community to continuously monitor various metabolites (glucose, lactate, sodium, etc.) in patients. Glucose microdialysis is of particular interest in diabetes treatment. Commercially available microdialysis probes have been used to create microdialysis sampling systems with a glucose biosensor. However, most probes are operated in a diffusion limited regime and struggle to obtain high recoveries of analytes. In this paper, an on-chip microdialysis system is presented. Dialysis of sulforhodamine fluorescent dye (MW 607) and glucose (MW 180) are demonstrated. The average permeability of the membrane to the fluorescent dye is 0.3471 μm/s (standard deviation (S.D.) 0.0235 μm/s) and is 2.5280 μm/s (S.D. 0.3723 μm/s) for glucose. The results of fluorescence and glucose dialysis show consistency and follow analytically predicted results. The system is sensitive to rapid changes in glucose reservoir concentration. Within 10 min of a reservoir concentration change, the outlet concentration of the dialysate has reached steady state with an 80% glucose recovery at a flowrate of 1.5 μl/min.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 107, Issue 2, 29 June 2005, Pages 649-656
Journal: Sensors and Actuators B: Chemical - Volume 107, Issue 2, 29 June 2005, Pages 649-656
نویسندگان
Yi-Cheng Hsieh, Jeffrey D. Zahn,