کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10410924 894532 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fabrication of microchip electrophoresis devices and effects of channel surface properties on separation efficiency
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Fabrication of microchip electrophoresis devices and effects of channel surface properties on separation efficiency
چکیده انگلیسی
This paper describes the influence of chip material on the separation efficiency in microchip electrophoresis using quartz, glass, polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and glass hybrid as the microchip material. The fabrication processes for each microchip are described in detail. We introduce a new fabrication method for a glass chip using amorphous silicon on the glass surface as an etch mask and a bonding interface for anodic bonding. The microchannel structures in each microchip were compared using a scanning electron microscope or profilometer. We investigated the mobilities and bandwidths of electroosmotic flow (EOF) and analytes in microchip electrophoresis. Significant band broadening was observed in a microchip composed of a hybrid material (glass and silicon dioxide membrane) compared with a microchip of single material due to the nonuniformity of the surface charge density.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 107, Issue 2, 29 June 2005, Pages 818-824
نویسندگان
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