کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10532705 961696 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantitative MUC5AC and MUC6 mucin estimations in gastric mucus by a least-squares minimization method
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Quantitative MUC5AC and MUC6 mucin estimations in gastric mucus by a least-squares minimization method
چکیده انگلیسی
We have determined the molar proportions of the MUC5AC and MUC6 mucus glycoproteins (mucins) in mucus from the normal and pathological human gastric antrum using a least-squares minimization analysis applied to amino acid compositions. We noted that the content of MUC5AC mucin in mucus from individuals without gastroduodenal disease was very high, suggesting that the integrity and barrier properties of the adherent gastric mucus layer are normally maintained by building-block structures formed from this mucin alone. We observed that the molar content of MUC6 mucin doubled (without significance) in mucus from patients with duodenal ulcer, and increased five times (with high significance) in mucus from patients with gastric ulcer, when compared with that in mucus from individuals without gastroduodenal disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytical Biochemistry - Volume 439, Issue 2, 15 August 2013, Pages 204-211
نویسندگان
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