کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10556355 | 968311 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Use of dried blood spots and inductively coupled plasma mass spectrometry for multi-element determination in blood
ترجمه فارسی عنوان
استفاده از لکه های خالی خشک شده و طیف سنجی جرمی پلاسما برای تعیین چند عنصر در خون
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The paper describes the development of an inductively coupled plasma mass spectrometry (ICP MS) method for multitrace element determination in dried blood spots (DBSs). The analytical conditions were optimized using Seronorm⢠L-3 and L-1 Certified Reference Materials. The best results were obtained by sampling blood drops on a decontaminated PVDF filter membrane. After drying under metal-free conditions, the DBSs underwent acidic digestion and were analyzed with ICP MS. The method was then validated for As, Cd, Cu, Pb, Mo, Se and Zn. Using a matrix-matched calibration curve, the recovery levels ranged from 96% to 117%. The repeatability and reproducibility were generally below 15%. Limits of quantification ranging from 0.5 to 50 μg/L. In order to investigate the analytical procedure under real sampling conditions, the results obtained from DBSs and liquid blood aliquots (less subject to contamination) from two adult subjects were compared.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Trace Elements in Medicine and Biology - Volume 28, Issue 3, July 2014, Pages 255-259
Journal: Journal of Trace Elements in Medicine and Biology - Volume 28, Issue 3, July 2014, Pages 255-259
نویسندگان
Véronique Vacchina, Vincent Huin, Sébastien Hulo, Damien Cuny, Franck Broly, Gilles Renom, Jean-Marc Perini,