کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10556370 968311 2014 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urine as a material for evaluation of exposure to manganese in methcathinone users
ترجمه فارسی عنوان
ادرار به عنوان یک ماده برای ارزیابی قرار گرفتن در معرض منگنز در متکاتینون کاربران
کلمات کلیدی
متکاتینون، ادرار مواد مخدر غیرقانونی، منگنز، سندروم پارکینسون،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Chronic exposure even to low doses of manganese may lead to development of neurological syndrome similar to parkinsonism. The aim of this research is to assess the possibility of manganese poisoning based on the level of metal in the urine of long-term methcathinone users from Poland. Graphite furnace atomic absorption spectroscopy (GFAAS) was used to determine manganese in urine, while the detection of the psychoactive drugs was performed by high-performance liquid chromatography (HPLC). Results of survey on longitudinal patterns of drug use showed that users of traditional illicit drugs now turn to cheaper alternatives, such as methcathinone. Parkinsonian features were observed in almost half of methcathinone users. The subjects had a higher mean level of Mn in their urine (8.68 ± 9.27 μg L−1) than the controls (4.27 ± 1.91 μg L−1). The presence of numerous psychoactive substances (in unchanged forms and their metabolites) was confirmed in all of the samples, with only one exception. The elevated level of manganese in urine (in 29.2% of patients) can be used as a primary marker of recent methcathinone administration, especially in the case of long time intravenous drug users where blood sampling is complicated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Trace Elements in Medicine and Biology - Volume 28, Issue 3, July 2014, Pages 338-343
نویسندگان
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