Synthesis of [18F]xenon difluoride as a radiolabeling reagent from [18F]fluoride ion in a micro-reactor and at production scale

[18F]XeF2 was produced in multi-mCi amounts from the reaction of [18F]fluoride ion with XeF2 in MeCN. The isolated [18F]XeF2 was reactive towards substrates, such as 1-((trimethylsilyl)oxy)cyclohexene and fluorene.