کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10579369 | 980261 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enantioselective synthesis of orthogonally protected (2R,3R)-(â)-epicatechin derivatives, key intermediates in the de novo chemical synthesis of (â)-epicatechin glucuronides and sulfates
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ten orthogonally protected (â)-epicatechin and 3â²- or 4â²-O-methyl-(â)-epicatechin derivatives were prepared in a regiospecific and enantioselective manner. For each orthogonally protected (â)-epicatechin derivative, one specific phenolic hydroxyl was protected with a methoxymethyl (MOM) or p-methoxybenyzl (PMB) group and the remainder were protected as benzyl ethers. These uniquely protected (â)-epicatechin derivatives were designed to facilitate the regiospecific installation of a glucuronic acid or sulfate unit onto (â)-epicatechin after selective removal of the MOM or PMB protecting group to provide authentic standards of (â)-epicatechin glucuronides and sulfates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron: Asymmetry - Volume 24, Issue 7, 15 April 2013, Pages 362-373
Journal: Tetrahedron: Asymmetry - Volume 24, Issue 7, 15 April 2013, Pages 362-373
نویسندگان
Mingbao Zhang, G. Jr., Michael Van Zandt, Paul Beckett, Hagen Schroeter,