1-Amino-1-ferrocenyl-2-methyl-2-propanol: a case study on the conformational control of asymmetric induction

The introduction of a gem-dimethyl moiety at C1 in 2-amino-2-ferrocenylethanol exerts a strong conformational control on the ferrocenyl group when this compound is incorporated into a heterocyclic ring, leading to increased levels of asymmetric induction in reactions mediated by chiral auxiliaries or ligands derived from this chiral β-amino alcohol.