Magnetic fluid thermochemotherapy of murine tumors

Four series of water-based dextran-ferrite (DF) magnetic fluids (MFs) containing Melphalan (MP) were prepared. Their saturation magnetization (Ms) was from 0.8 to 7.8 kA/m; specific power absorption rates were 240 W/g Fe. After nine courses of magnetic fluid thermochemotherapy with MP containing DF MF (Ms 7.5 kA/m, pH 6.6, ζ+15 mV) at 44-46 °C for 30 min in an AC magnetic field (0.88 MHz, 9.3 kA/m, 0.3 kW), complete P388 tumor regression was seen in 30% of BDF1 mice. Furthermore, a life span increase of 180% was achieved.