Onset of power-law scaling behavior in idiotypic random and scale-free networks

► We investigate the outcome of a model for B-cell clonal dynamics. ► The model follows Jerneʼs idiotypic theory. ► The response of the immune system to different network topologies is addressed. ► Complex scaling behavior is observed in the idiotypic network. ► We analyze the possibility of local versus spread out (possibly autoimmune) response of the immune system.