کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10744855 | 1048696 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence
ترجمه فارسی عنوان
اختلالات حرکتی معده در بیماری پارکینسون: شواهد بالینی پیشین
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کلمات کلیدی
بیماری پارکینسون، تحرک معده، تومور عصبی عضلانی معده، مدل های پیش از بیماری پارکینسون،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Parkinson's disease (PD) is associated with several non-motor symptoms, such as behavioral changes, urinary dysfunction, sleep disorders, fatigue and, above all, gastrointestinal (GI) dysfunction, including gastric dysmotility, constipation and anorectal dysfunction. Delayed gastric emptying, progressing to gastroparesis, is reported in up to 100% of patients with PD, and it occurs at all stages of the disease with severe consequences to the patient's quality of life. The presence of α-synuclein (α-syn) aggregates in myenteric neurons throughout the digestive tract, as well as morpho-functional alterations of the enteric nervous system (ENS), have been documented in PD. In particular, gastric dysmotility in PD has been associated with an impairment of the brain-gut axis, involving the efferent fibers of the vagal pathway projecting directly to the gastric myenteric plexus. The present review intends to provide an integrated overview of available knowledge on the possible role played by the ENS, considered as a semi-autonomous nervous network, in the pathophysiology of gastric dysmotility in PD. Particular attention has been paid review how translational evidence in humans and studies in pre-clinical models are allowing a better understanding of the functional, neurochemical and molecular alterations likely underlying gastric motor abnormalities occurring in PD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 21, Issue 12, December 2015, Pages 1407-1414
Journal: Parkinsonism & Related Disorders - Volume 21, Issue 12, December 2015, Pages 1407-1414
نویسندگان
Carolina Pellegrini, Luca Antonioli, Rocchina Colucci, Vigilio Ballabeni, Elisabetta Barocelli, Nunzia Bernardini, Corrado Blandizzi, Matteo Fornai,