کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10746104 | 1048752 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease
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کلمات کلیدی
NIRVTAPAGMPTPSubstantia nigra pars reticulataMAQSNCSNR1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridineadenosine-5′-triphosphate - آدنوزین 5'-تری فسفاتATP - آدنوزین تری فسفات یا ATPthird ventricle - بطن سومsubstantia nigra - توده سیاهsubstantia nigra pars compacta - توده سیاه پارس متراکمtyrosine hydroxylase - تیروزین هیدروکسیلازmammillothalamic tract - دستگاه ماملیوتالاموسLight emitting device - دستگاه نوریLED - رهبریPeriaqueductal grey matter - ماده خاکستری پرایاکوداکتNeuroprotection - محافظت نورونی یا محافظت از عصبzona incerta - منطقه نامشخصventral tegmental area - ناحیه تگمنتوم شکمیNear-infrared light - نور مادون قرمز نزدیکHypothalamus - هیپوتالاموس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease](/preview/png/10746104.png)
چکیده انگلیسی
We have shown previously that photobiomodulation or near-infrared light (NIr) treatment protects dopaminergic cells of the substantia nigra pars compacta (SNc) in an acute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). In this study, we tested the protective and rescue action of NIr treatment in a chronic MPTP model, developed to resemble more closely the slow progressive degeneration in PD patients. We examined three regions of dopaminergic cells, the SNc, periaqueductal grey matter (PaG) and zona incerta-hypothalamus (ZI-Hyp). BALB/c mice had MPTP or saline injections over five weeks, followed by a three-week survival. NIr treatment was applied either at the same time as (simultaneous series) or after (post-treatment series) the MPTP insult. There were four groups within each series; Saline, Saline-NIr, MPTP and MPTP-NIr. Brains were processed for tyrosine hydroxylase (TH) immunochemistry and cell number was analysed using the optical fractionator method. In the SNc, there was a significant reduction (â¼45%) in TH+ cell number in the MPTP groups compared to the saline controls of both series. In the MPTP-NIr groups of both series, TH+ cell number was significantly higher (â¼25%) than in the MPTP groups, but lower than in the saline controls (â¼20%). By contrast in the PaG and ZI-Hyp, there were no significant differences in TH+ cell number between the MPTP an MPTP-NIr groups of either series. In summary, exposure to NIr either at the same time or well after chronic MPTP insult saved many SNc dopaminergic cells from degeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 18, Issue 5, June 2012, Pages 469-476
Journal: Parkinsonism & Related Disorders - Volume 18, Issue 5, June 2012, Pages 469-476
نویسندگان
Cassandra Peoples, Sharon Spana, Keyoumars Ashkan, Alim-Louis Benabid, Jonathan Stone, Gary E. Baker, John Mitrofanis,