کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10818967 | 1060290 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
S-nitrosoglutathione-induced toxicity in Drosophila melanogaster: Delayed pupation and induced mild oxidative/nitrosative stress in eclosed flies
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کلمات کلیدی
GSTDTNBGSNOS-nitrosoglutathioneG6PDHICDHNADP-dependent isocitrate dehydrogenaseGSH/GSSG - GSH / GSSGEDTA - اتیلن دی آمین تترا استیک اسید ethylene diamine tetraacetate - اتیلن دیامین تتراسیتاتglutathione-S-transferase - گلوتاتیون S-ترانسفرازreduced/oxidized glutathione - گلوتاتیون کاهش / اکسید شدهglucose-6-phosphate dehydrogenase - گلوکز 6-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The toxicity of the nitric oxide donor S-nitrosoglutathione (GSNO) was tested on the Drosophila melanogaster model system. Fly larvae were raised on food supplemented with GSNO at concentrations of 1.0, 1.5 or 4.0Â mM. Food supplementation with GSNO caused a developmental delay in the flies. Biochemical analyses of oxidative stress markers and activities of antioxidant and associated enzymes were carried out on 2-day-old flies that emerged from control larvae and larvae fed on food supplemented with GSNO. Larval exposure to GSNO resulted in lower activities of aconitase in both sexes and also lower activities of catalase and isocitrate dehydrogenase in adult males relative to the control cohort. Larval treatment with GSNO resulted in higher carbonyl protein content and higher activities of glucose-6-phosphate dehydrogenase in males and higher activities of superoxide dismutase and glutathione-S-transferase in both sexes. Among the parameters tested, aconitase activity and developmental end points may be useful early indicators of toxicity caused by GSNO.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 164, Issue 1, January 2013, Pages 162-170
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 164, Issue 1, January 2013, Pages 162-170
نویسندگان
Oleksandr V. Lozinsky, Oleh V. Lushchak, Natalia I. Kryshchuk, Natalia Y. Shchypanska, Anna H. Riabkina, Stanislava V. Skarbek, Ivan V. Maksymiv, Janet M. Storey, Kenneth B. Storey, Volodymyr I. Lushchak,