کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10819132 | 1060358 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Biochemical studies have established the presence of a NO pathway in the heart, including sources of NO and various effectors. Several cardiac ion channels have been shown to be modified by NO, such as L-type Ca2+, ATP-sensitive K+, and pacemaker f-channels. Some of these effects are mediated by cGMP, through the activity of three main proteins: the cGMP-dependent protein kinase (PKG), the cGMP-stimulated phosphodiesterase (PDE2) and the cGMP-inhibited PDE (PDE3). Other effects appear independent of cGMP, as for instance the NO modulation of the ryanodine receptor-Ca2+ channel. In the case of the cardiac L-type Ca2+ channel current (ICa,L), both cGMP-dependent and cGMP-independent effects have been reported, with important tissue and species specificity. For instance, in rabbit sinoatrial myocytes, NO inhibits the β-adrenergic stimulation of ICa,L through activation of PDE2. In cat and human atrial myocytes, NO potentiates the cAMP-dependent stimulation of ICa,L through inhibition of PDE3. In rabbit atrial myocytes, NO enhances ICa,L in a cAMP-independent manner through the activation of PKG. In ventricular myocytes, NO exerts opposite effects on ICa,L: an inhibition mediated by PKG in mammalian myocytes but by PDE2 in frog myocytes; a stimulation attributed to PDE3 inhibition in frog ventricular myocytes but to a direct effect of NO in ferret ventricular myocytes. Finally, NO can also regulate cardiac ion channels by a direct action on G-proteins and adenylyl cyclase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 142, Issue 2, October 2005, Pages 136-143
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 142, Issue 2, October 2005, Pages 136-143
نویسندگان
Rodolphe Fischmeister, Liliana Castro, Aniella Abi-Gerges, Francesca Rochais, Grégoire Vandecasteele,