کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10819187 | 1060365 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of hypoxia on the venous circulation in rainbow trout (Oncorhynchus mykiss)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Hypoxia in fish is generally associated with bradycardia while cardiac output (QË) remains unaltered or slightly increased due to a compensatory increase in stroke volume (SV). Rainbow trout (Oncorhynchus mykiss) were subjected to severe (PWO2=7.3±0.2 kPa) or mild (PWO2=11.5±0.2 kPa) hypoxia. Central venous pressure (Pven), dorsal aortic pressure (Pda), heart rate (fH) and QË, were recorded in vivo. Both levels of hypoxia triggered a significant increase in Pven. Severe hypoxia was associated with bradycardia and unaltered QË, whereas mild hypoxia was associated with a small but significant increase in QË and no bradycardia. These findings indicate that an increase in Pven promotes an increase in SV during hypoxia. Since mild hypoxia increased Pven, QË and SV without bradycardia or reduced systemic resistance (Rsys), we hypothesize that an active increase in venous tone serving to mobilize blood to the central venous compartment in order to increase cardiac preload and consequently SV, is an important cardiovascular trait associated with hypoxia. Pharmacological pre-treatment with prazosin (1 mg kg-1) did not conclusively reveal the underlying mechanisms to the observed changes in Pven. This study discusses the influence of venous pooling, reduced Rsys and altered venous tone on changes in Pven observed during hypoxia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 140, Issue 2, February 2005, Pages 233-239
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 140, Issue 2, February 2005, Pages 233-239
نویسندگان
E. Sandblom, M. Axelsson,