The anti-inflammatory and anti-apoptotic effects of nesfatin-1 in the traumatic rat brain

► Nesfatin-1 may inhibit nuclear factor kappa-B-dependent inflammatory responses after traumatic brain injury in rats. ► Nesfatin-1 may lessen caspase-3-mediated neuronal cell apoptosis after traumatic brain injury in rats. ► Nesfatin-1 may ameliorate the inflammation and furthermore reduce neuronal cell apoptosis after traumatic brain injury in rats.