TLQP-21, a VGF-derived peptide, stimulates exocrine pancreatic secretion in the rat

► TLQP-21 increases exocrine secretion from pancreatic rat lobules. ► The stimulatory effect on enzyme outflow is indirect and involves PGs release. ► TLQP-21 is an anorexigenic signal acting in the peripheral control of satiety. ► TLQP-21 is a tool to investigate on the systems regulating pancreatic secretion.