Chronic effects of centrally administered adiponectin on appetite, metabolism and blood pressure regulation in normotensive and hypertensive rats

► Chronic CNS adiponectin infusion does not alter appetite or energy expenditure in Sprague-Dawley rats. ► Chronic CNS adiponectin infusion reduces appetite and improves insulin sensitivity in SHRs. ► Chronic CNS adiponectin treatment does not exert major chronic effects on BP and HR.