Central administration of oxytocin reduces hyperalgesia in mice: Implication for cannabinoid and opioid systems

► Icv oxytocin administration reduces carrageenan-induced hyperalgesia. ► CB1 receptor is involved in oxytocin-induced antihyperalgesic effect. ► μ- and κ-opioid receptor subtypes play a key role in OXT-induced antihyperalgesic effect. ► Central oxytocin does not reduce carrageenan-induced paw edema.