Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty

► Kisspeptin levels do not change throughout puberty in males. ► Kisspeptin are higher in adult females than in prepubertal and pubertal females. ► Kisspeptin is elevated in prepubertal obese girls but not in idiopathic CPP girls. ► Kisspeptin does not seem to be a good marker for pubertal disorders. ► Adipose tissue may contribute to circulating kisspeptin synthesis.