The bradykinin B1 receptor antagonist R-954 inhibits Ehrlich tumor growth in rodents

► The effects of the bradykinin B1 antagonist R-954 were evaluated on the inflammatory reaction associated with the progression of Ehrlich ascitic tumor in mice and rats. ► R-954 reduced the inflammatory mediators, tumor growth as well as total cell numbers in medulla, blood, and ascitic fluid which follow the tumor inoculation. ► R-954 also inhibited the increase of solid tumor inoculated in rat paw.