Biological properties of prolactin-releasing peptide analogs with a modified aromatic ring of a C-terminal phenylalanine amide

► PrRP20 analogs with changes at C-terminal Phe amides were characterized. ► PrRP20 analogs showed high affinities for the GPR10 receptor and cell signaling. ► PrRP20 analogs showed highly significant and long-lasting anorexigenic effect.