Lipopolysaccharide increases gastric and circulating NUCB2/nesfatin-1 concentrations in rats

► LPS reduces plasma acyl ghrelin and desacyl ghrelin levels. ► In contrast, circulating nesfatin-1 is increased. ► Increased nesfatin-1 levels under these conditions are likely to be stomach derived. ► These data highlight the differential regulation of ghrelin and nesfatin-1. ► Decreased ghrelin and increased nesfatin-1 likely contribute to the LPS-induced anorexia.