An evolutionary comparison of leucine-rich repeat containing G protein-coupled receptors reveals a novel LGR subtype

► We confirmed the division of leucine-rich repeat containing GPCRs into types A-C. ► We identified a subdivision of type C LGRs into type C1 and newly identified C2. ► Type C1 is characterized by a single LDLa module, C2 has multiple. ► A possible ancestral form of LGRs was revealed in Placozoa.