کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10835831 1066337 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel peptide for attenuation of hypoxia-induced pulmonary hypertension via modulation of nitric oxide release and phosphodiesterase -5 activity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Novel peptide for attenuation of hypoxia-induced pulmonary hypertension via modulation of nitric oxide release and phosphodiesterase -5 activity
چکیده انگلیسی
► Peptide therapy attenuates hypoxia-induced pulmonary artery hypertension and vascular remodeling. ► The effect was found to be mediated by increased NO-release and inhibition of cGMP-specific PDE-5. ► Dual action of the peptide that enhance NO release and diminished PDE-5 activity resulted in sustained elevation of cGMP. ► This novel peptide has therapeutic potential for NO/cGMP-dependent modulation of hemodynamic and structural changes in the pulmonary circulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 35, Issue 1, May 2012, Pages 78-85
نویسندگان
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