Developmental overfeeding alters hypothalamic neuropeptide mRNA levels and response to a high-fat diet in adult mice

► We studied hypothalamic neuropeptide expression in developmentally overfed mice. ► Breast and/or adolescence overfed adult mice had reduced NPY mRNA levels. ► Adult high fat diet further reduced neuropeptide levels in developmentally overfed mice. ► Several peptidergic circuits are altered in developmentally overfed adult mice.