Adrenomedullin protects against fructose-induced insulin resistance and myocardial hypertrophy in rats

► Endogenous ADM was increased in rats with insulin resistance induced by fructose. ► ADM has protective effect on fructose-induced insulin resistance. ► ADM inhibited cardiovascular hypertrophy associated with insulin resistance. ► ADM could act as a protective peptide against IR probably via its antioxidant effect.