Shared and separate functions of the RAMP-based adrenomedullin receptors

► AM is a novel hypotensive peptide that exerts a variety of strongly protective effects against multiorgan damage. ► Many of the effects of AM are mediated via the RAMP2-based AM1 receptor. ► The evidence now suggests that the RAMP3-based AM2 receptor also has distinct functions in vivo. ► AM2 is an AM-related peptide whose biological actions are similar to those of AM. ► AM2 strongly interacts with the AM1 and AM2 receptors and may also bind to a unique receptor.