Gastrin releasing peptide-29 requires vagal and splanchnic neurons to evoke satiation and satiety

► Gastrin-releasing peptide-29 reduces MS (10% sucrose) and prolongs IMI. ► We tested MS and IMI by GRP-29 in VGX and CMGX rats. ► We also tested, by myotomy, if the duodenum is the site of action. ► CMGX and VGX/CMGX attenuated MS and all surgeries attenuated the IMI. ► MS and IMI by GRP-29 require duodenal vagal and splanchnic nerves.