Central apelin-13 inhibits food intake via the CRF receptor in mice

► Apelin-13 inhibited food and water intake in satiated mice during dark period. ► Apelin-13 inhibited food and water intake in fasted mice during dark period. ► Apelin-13 had no role in food and water intake in satiated mice during light period. ► The apelin-13(F13A) and α-helical CRF9-41 blocked the effect of apelin-13 on feeding. ► The deamino(CH2)5Tyr(Me)AVP could not antagonize the action of apelin-13 on feeding.