Differential regulation of gonadotropin-releasing hormone by corticotropin-releasing factor family peptides in hypothalamic N39 cells

► There is a close interaction between the HPG axis and the HPA axis. ► CRF and Ucn2 can modulate GnRH mRNA and protein levels via each specific CRF receptor subtype in N39 cells. ► Differential regulation of GnRH by CRF family peptides contributes to the stress response and homeostasis in the GnRH cells.