Modulation of neuropeptide FF (NPFF) receptors influences the expression of amphetamine-induced conditioned place preference and amphetamine withdrawal anxiety-like behavior in rats

► NPFF inhibits amphetamine-induced CPP. ► NPFF receptors antagonist, RF9 reverses anxiety-like effect of amphetamine withdrawal. ► Modulation of NPFF receptors modifies the expression of amphetamine-induced CPP and amphetamine withdrawal anxiety.