Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility

► We compare the effects of ghrelin, des-acyl ghrelin and obestatin on the GI motility. ► To examine the brain-gut interaction we used conscious rat model for manometric measurement of GI motility. ► Involvement of hypothalamic peptides was also examined. ► Ghrelin, des-acyl ghrelin and obestatin exert different effects on the GI motility. ► In their actions, different hypothalamic peptides are involved.