Ghrelin inhibited serotonin release from hippocampal slices

► We studied the effect of Ghrelin (Ghr) upon the release of 5-HT in hippocampus. ► We used hippocampal slices pre-changed with [3H]5-HT. ► The presence of Ghr in the superfusion medium decreases the release of 5-HT. ► The in vivo intra-hippocampal administration of Ghr decreases the neurotransmitters release. ► Ghr as well as other peptides could modulate the release of neurotransmitters.