Amylin effect in extrapancreatic tissues participating in glucose homeostasis, in normal, insulin-resistant and type 2 diabetic state

► In liver, amylin normalizes mRNA-GLUT-2 and glycogen content IR and T2D rats. ► In muscle, amylin normalizes the reduced glycogen synthase a activity in IR rats. ► In adipocytes, amylin normalizes altered glucose transport (GT) in IR and T2D rats. ► In adipocytes, amylin highly improves insulin-induced GT in N, IR and T2D rats.