Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice

► The role of gastrin-releasing peptide released from primary afferent on itch was demonstrated. ► Gastrin-releasing peptide elicits scratching, an itch-related response, in mice though BB2 bombesin receptor. ► Gastrin-releasing peptide-induced scratching is inhibited by H1 histamine receptor antagonists and PAR2 proteinase-activated receptor antagonist. ► Gastrin-releasing peptide-induced scratching may be elicited through the activation of mast cells.